The proper way to take Methylprednisolone tablets varies from disease to disease, and the initial dose can be adjusted between 4mg and 48mg per day. Methylprednisolone is a synthetic glucocorticoid and is commonly used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, pemphigus and other diseases. The initial dose of methylprednisolone tablets is adjusted between 4mg and 48mg per day depending on the treatment needs of the different diseases. Lower doses are usually sufficient for milder symptoms; certain patients, such as those with multiple sclerosis and cerebral edema, may require higher doses. Methylprednisolone tablets should be used under the supervision of a healthcare professional; possible adverse reactions include infection, sodium retention, gastric bleeding, etc. Methylprednisolone tablets are contraindicated in people who are allergic to methylprednisolone tablets, in people with systemic fungal infections, and the use of live or live attenuated vaccines is contraindicated in patients being treated with corticosteroid immunosuppressive dosages.