Irritability and anxiety can be seen clinically in anxiety disorders as well as schizophrenia. Anxiety disorders are considered when the patient is predominantly inexplicably tense, worried, frightened, and fearful, accompanied by plant nerve dysfunction as well as fidgeting and inability to sit still. Anxiety disorders are a relatively common type of neurological disorder in clinical practice, and clinical treatment is based on systematic treatment with anti-anxiety and antidepressant drugs. When the patient’s mood is irritable and anxious, and is produced under the basis of hallucinations and delusions, and is dominated by hallucinations and delusions, accompanied by cognitive, emotional, and thinking dissonance as the main content, then schizophrenia needs to be considered. Once the diagnosis of schizophrenia is confirmed, systematic treatment with antipsychotic medication is required. Therefore, for mood irritability and anxiety, there will be a wide variety of clinical disorders. A clear diagnosis should be made during clinical treatment, and then systematic and standardized treatment should be used to achieve good treatment results.