Erythromycin Isotretinoin Gel is a commonly used medication for the treatment of acne in the clinic. If a layer of dry skin appears after applying Erythromycin Isotretinoin Gel, it may be an adverse reaction, and it is recommended that patients continue to use the drug or stop using it under the guidance of a doctor. Erythromycin isotretinoin gel for acne works by promoting the differentiation of skin epithelial cells and has a local anti-inflammatory effect. Adverse effects such as peeling, stinging, and erythema may occur during treatment, and when this occurs, patients are advised to decide whether or not to use the medication for treatment under the supervision of a physician. Generally with continued use of the drug, these adverse reactions may gradually disappear. If severe irritation occurs, suspension of use is recommended. When patients experience adverse reactions after applying Erythromycin Isotretinoin Gel, it is recommended that they go to the hospital in time for examination and treatment under the guidance of a professional doctor.