You should not drink alcohol twenty-four hours after taking metronidazole, or a disulfiram-like reaction may occur. Metronidazole belongs to the nitroimidazole class of drugs, after the use of alcohol may occur disulfiram-like reaction. Under normal circumstances, after drinking alcohol, alcohol will be decomposed and metabolized under the action of acetaldehyde dehydrogenase. However, the use of drugs such as metronidazole will inhibit the activity of acetaldehyde dehydrogenase, which will interfere with the decomposition and metabolism of alcohol in the body and increase the level of acetaldehyde in the blood, resulting in a series of reactions. Disulfiram reaction usually occurs in about 5 minutes to an hour after the contact between the drug and the alcohol products, the patient may have systemic symptoms, such as lower or higher blood pressure, ECG abnormalities, angina pectoris, headache, dizziness, respiratory distress, near-death feeling, or even shock, etc., and the serious ones will be life-threatening. In addition to taking metronidazole can not drink alcohol, the use of cephalosporin drugs, hypoglycemic drugs, etc., can not drink alcohol, it is recommended that three days before the use of medication as well as 7 days after the use of drugs do not drink alcohol, but also do not consume food or drugs containing alcohol. The above medications should be used under the guidance of a doctor, standardized use, avoid self-medication, so as not to cause adverse consequences.