Callus is usually called callus in medicine, hand long callus cracking and peeling can take general treatment, medication, physical therapy and other ways to improve. 1. General treatment: for patients with long callus cracking and peeling, should avoid friction and extrusion of the affected area, and keep the local clean, avoid tearing the skin flakes, otherwise the condition may be aggravated. 2. Drug treatment: patients can follow the doctor’s instructions for external use of salicylic acid and other drugs, with the role of softening and dissolving keratin. In addition, you can also follow the doctor’s instructions to apply retinoic acid ointment, urea cream and other drugs, with exfoliation, moisturizing the skin, which can help improve local symptoms. 3. Physical therapy: Liquid nitrogen cryotherapy and carbon dioxide laser therapy are physical therapy, which can help exfoliate keratinocytes and repair skin lesions. Patients should choose whether to use them according to their own situation and follow the doctor’s instructions. There are many ways to improve the hand callus cracking and peeling, and it is recommended that patients go to the hospital and cooperate with the doctor for standardized treatment.