Glimepiride and Glycine Insulin can be used together, but it is important to be careful with the dosage, monitor your blood sugar, and apply it strictly under your doctor’s supervision. Glimepiride is an insulinotropic agent mainly used for the treatment of type 2 diabetes. Possible adverse reactions include hypoglycemia, weight gain, and gastrointestinal reactions. Contraindications include hypersensitivity to the product, type 1 diabetes mellitus, ketoacidosis, and severe renal or hepatic impairment. Glycitin insulin is a long-acting insulin. Possible adverse reactions include hypoglycemia, weight gain, and allergy. Contraindications include allergy to the product, etc. Glimepiride and Glycine Insulin can be used together, but both may have the adverse effect of hypoglycemia, and the combination of the two should be used with attention to dosage, as well as monitoring of blood glucose, to guard against the occurrence of hypoglycemia. Drugs should be applied under the guidance of a doctor, do not apply on your own.