After taking drugs for tuberculosis, the skin may turn black, which may be caused by the photosensitizing effect of the drugs or liver damage. 1. Photosensitization of drugs: such as pyrazinamide, levofloxacin and other drugs, these drugs have photosensitization effect, which can promote the melanocyte vitality of the skin to enhance, long-term oral intake will make the skin darken or appear obvious small spots. 2. Liver damage: anti-tuberculosis drugs are metabolized in the liver, which may cause some damage to liver function, and when liver function is damaged, it may lead to darkening of the skin or the occurrence of small spots. When patients taking drugs for the treatment of tuberculosis appear skin darkening state, generally do not need to worry. The dosage of medication must be strictly in accordance with the doctor’s instructions, and should not be increased or decreased without authorization or taken privately, so as not to cause further aggravation of the condition.