Sharp ankle pain, unable to walk mostly refers to sharp ankle pain with activity limitation, according to the different causes of the treatment program is also different, the common causes are trauma, gout, vascular occlusion and so on. 1. Trauma: because of strenuous exercise, car accidents, jumping from a high place and other reasons leading to ankle injuries, common soft tissue injuries, Achilles tendon rupture, Achilles fracture and so on. Treatment can be intermittent cold compresses to reduce swelling within 72 hours after the injury, hot compresses to promote swelling after 72 hours, oral non-steroidal anti-inflammatory drugs, such as acetylchlorophenic acid extended-release tablets, lower limb plaster external fixation, serious cases such as Achilles tendon rupture, calcaneal comminuted fracture with obvious displacement requires surgical treatment. 2. Gout: It is caused by eating seafood and animal offal for a long time, which leads to hyperuricemia, and the deposition of urate in the ankle joint and the surrounding tissues causes inflammatory reaction. Symptoms such as ankle joint pain, activity limitation and skin fever can occur. Diet control and oral treatment with drugs such as febuxostat and colchicine are needed. 3. Vascular occlusion: Because of high blood pressure, hyperlipidemia and other reasons, resulting in hypercoagulable state of blood, causing occlusion of blood vessels in the lower limbs, insufficient blood and oxygen supply to the tissues, and necrosis, which can lead to severe pain in the lower limbs and limitation of activities. It is necessary to actively control blood pressure and blood lipid, and use blood activating drugs such as thrombolytic injection. Causes of ankle joint pain with activity limitation are more reasons, may also be related to diabetes complications, bone tumors and other diseases, specific treatment options, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease, targeted treatment, the above drugs should be used under the guidance of a doctor.