Sibutramine is a central nervous system depressant that acts on the central nervous system and can provide some appetite control and thus weight loss. If sibutramine is taken in small amounts, it can be detoxified by taking large amounts of warm water and by promoting diuresis. However, if a large amount of sibutramine is taken by mistake, it must be detoxified through formal detoxification methods. The detoxification method can be adopted by taking 5000-7500ml of warm water when the patient is awake and then picking the throat to induce vomiting, so that all the sibutramine not completely digested and absorbed by the gastrointestinal tract can be vomited out. You can also take the catheterization method, you can instill mannitol for catheterization, which can remove part of the sibutramine absorbed by the intestine in the digestive tract. In addition, injectable vitamin C should be administered intravenously, which has a detoxifying effect. Hydrochlorothiazide or furosemide can also be taken to increase the diuretic function, which can metabolize sibutramine hydrochloride through urine, and all of the above can have a detoxifying effect.