Eisenmenger syndrome is a consequence of the development of a group of congenital heart diseases such as atrial septal defect, ventricular septal defect, and patent ductus arteriosus. The original left-to-right shunt is called Eisenmenger syndrome when a right-to-left shunt develops due to untimely treatment and progressive pulmonary hypertension, with a gradual appearance of cyanosis from normal skin color. When the disease has progressed to this stage, it is no longer surgically treatable or surgery is not effective, and medication can be chosen for symptomatic treatment to improve the quality of life. Female patients must choose contraception at this time, as the mortality rate is extremely high in both normal deliveries and cesarean sections, and if pregnancy is inadvertently terminated, it should be terminated immediately. In terms of medication, patients with Eisenmenger syndrome with respiratory distress can choose digoxin treatment, and diuretics such as hydrochlorothiazide can be chosen for lower limb edema, which can reduce the burden on the heart and relieve symptoms. Home patients can improve the symptoms of myocardial hypoxia with frequent oxygen intake. In conclusion, the presence of Eisenmenger syndrome surgery should be cautious.