The site of pleural puncture is not particularly certain and depends mainly on whether the pleural cavity is filled with gas or fluid. If it is gas, the puncture site should be more upward, mostly in the 2nd intercostal area of the midclavicular line, where the gas can drain more freely after puncture. If the puncture is for fluid, it depends on the patient’s position. If the patient is seated, the fluid should be more downward, so the puncture site should be more downward. If the fluid is more posterior when the patient is lying down, the puncture site should also be more posterior. At present, most of the punctures are performed by chest radiograph or ultrasound, and it is safer to perform the puncture under the guidance of ultrasound and chest radiograph positioning.