Irbesartan is usually taken once a day when combined with nifedipine. Irbesartan belongs to the angiotensin II receptor antagonist, mainly used for the treatment of essential hypertension, combined with hypertension, type 2 diabetic nephropathy, etc., the average patient once a day can be, after taking the drug there may be headache, dizziness, panic and other adverse reactions, but generally to a lesser extent, allergic to the product is prohibited. It is prohibited for pregnant women in the 4th to 9th month of pregnancy and lactating women. Nifedipine is a calcium antagonist, which can be used for all types of hypertension, and even has a good effect on stubborn and severe hypertension. However, it is important to note that it is contraindicated in women during pregnancy, cardiogenic shock, decompensated heart failure, and used with caution in patients with hypotension. Combined use of drugs to follow the doctor’s instructions, long-term drug administration should not be abruptly stopped, do not stop taking the drug, to avoid the phenomenon of rebound blood pressure increase.