The carcinogenic mechanism of betel nut is mainly related to the physical damage to the oral mucosa and its chemical composition during chewing. 1. Physical damage: when chewing betel nut, the friction of betel nut fibers can cause physical damage to the oral mucosa. Long-term damage to the oral mucosa, which is not healed, can lead to local chronic inflammation and even cancer. 2. Chemical composition: betel nut contains many kinds of alkaloids and polyphenols, all of which are biotoxic, among which betel nut alkaloid is the most important component, which is cytotoxic, and can promote the apoptosis of epithelial cells, interfere with the precipitation of extracellular matrix macromolecules and degradation process, which can induce cancer. Betel nut is recognized by the World Health Organization as a class of carcinogens, life should minimize the consumption of betel nut, if you feel sick need to go to the hospital.