Survival of Down’s syndrome children is variable, with most surviving beyond the age of 10 years and some surviving beyond the age of 50 years. About 50% of Down’s children have congenital heart disease, followed by digestive malformations and an increased incidence of acute lymphoblastic leukemia. Children with Down’s syndrome are immunocompromised and susceptible to infectious diseases. There is no specific figure for the survival of Down’s babies, and the majority of those who survive to adulthood develop dementia after the age of 30. Advances in medical technology have lengthened the survival time of Down’s babies, and Down’s babies with less severe heart malformations can be treated surgically to prolong survival. Children with Down’s syndrome can achieve self-care through long-term education and exercise. Prevention of infection and improvement of quality of life can prolong the survival of Down’s babies. There is no cure for Down’s syndrome. Pregnant women who discover Down’s syndrome during prenatal period should consult prenatal clinic in time, give genetic counseling under the guidance of doctors, and terminate pregnancy if necessary.