Hepatitis B minor bi-yang refers to positive hepatitis B surface antigen and hepatitis B core antibody. There is no literature on the probability of Hepatitis B minor bi-yang turning negative. Hepatitis B small two-positive is an intermediate state after hepatitis B virus infection, which is mainly the intermediate state of big three-positive to small three-positive or small three-positive to big three-positive. Normally, Hepatitis B Minor II Yang does not turn negative, but in cases of severe hepatitis and liver failure, it can lead to Hepatitis B Minor II Yang turning negative. In addition to this, in antiviral treatment, it is also possible to occur hepatitis B small two yang conversion. However, there is a lack of scientific evidence on the rate of conversion and further clinical studies are needed. Hepatitis B small two yang patients should be actively treated under the guidance of the doctor.