A Down syndrome risk rate of 1:91 suggests a high risk for Down’s syndrome screening and pregnant women should undergo further testing. Down’s syndrome screening is a mid-pregnancy screening method for Down’s syndrome, which can indicate the risk of the fetus having Down’s syndrome, in general, the normal low value is 1:1000, the normal high value is 1:270, the Down’s syndrome risk rate of 1:91 is higher than the highest value of the normal range of Down’s screening, suggesting that Down’s screening is high risk, and the possibility that the fetus is a Down’s baby is high. When Down’s syndrome screening suggests high risk, pregnant women need to undergo further tests to confirm whether the fetus is a Down’s syndrome baby. Commonly used testing methods include non-invasive DNA testing, amniocentesis, etc. After diagnosis, labor should be induced as soon as possible. When the results of Down’s syndrome screening are abnormal, further examination should be carried out under the guidance of specialized physicians, and the pregnancy should be terminated in time if necessary to avoid adverse pregnancy outcomes.