Insensitivity to anesthetic drugs in general is a condition that occurs during local anesthesia. First of all, because local anesthesia is where the doctor injects the anesthetic drug around the nerve with experience, only when the anesthetic actually infiltrates near the nerve and attaches to the nerve can the nerve be blocked to achieve the anesthetic effect. The doctor cannot clearly see the location of each nerve when injecting anesthetics and cannot ensure that the anesthetics are injected into the appropriate area without any difference. Moreover, local anesthesia depends on the blocking effect of the drug on the nerve, which is related to the concentration and effective volume of the drug and is not completely under the control of the doctor. Secondly, insensitivity to anesthetic drugs is also called resistance to anesthetic drugs, which is clinically known as drug resistance. This human body difference is related to the fact that different people have different needs for the amount of anesthetic drugs during the implementation of anesthesia, for example, people who often drink alcohol need an appropriate increase in the amount of drugs when using anesthetic drugs. When using anesthetic drugs, you should inform your doctor in advance of your condition so that he or she can choose the appropriate anesthetic drug and dosage.