If there is focal squamous epithelial papillary hyperplasia detected by gastroscopy, most of them can not be cured by themselves, and can be treated endoscopically or surgically under the guidance of specialized physicians. Focal squamous epithelial hyperplasia in the epithelium of the esophageal mucosa of the patient may be caused by repeated stimulation of long-term inflammation, if the esophageal mucosa is subjected to repeated stimulation of long-term inflammation, it will make the mucosa damaged, and the process of long-term damage repair will result in the gradual occurrence of fibrous tissue hyperplasia at the site of the damage, and the formation of raised masses on the surface of the mucosa, which will be manifested as focal squamous epithelial hyperplasia. This kind of hyperplasia cannot be detached naturally and can be treated by endoscopic stripping or surgery. If the hyperplasia is accompanied by atypical hyperplastic changes, it will further develop into esophageal cancer, so the above situation needs to be treated in time. When the patient’s examination reveals the presence of squamous epithelial papillary hyperplasia in the mucosal epithelium of the esophagus, it is recommended to listen to the doctor’s advice and carry out the treatment in time in order to avoid delaying the condition.