Biliary polyps are often ineffective when treated with medications alone and are usually managed clinically with surgical therapy. Cholesterol-depositing gallbladder polyps can be treated with statins such as Rosuvastatin, which may inhibit the progression of the polyps to some extent. For inflammatory polyps, treatment with antibiotics such as quinolones may be tried and may help to provide some relief. However, it is worth noting that the efficacy of the above two drug therapies is not clear in clinical practice, and the use of the relevant drugs should be in accordance with medical advice. At present, the clinically recognized treatment for multiple gallbladder polyps is still based on surgical treatment, such as laparoscopic cholecystectomy. It is recommended that people with multiple gallbladder polyps should seek timely medical treatment and decide on the most appropriate treatment plan under the guidance of a professional physician to maximize the prognosis.