The treatment plan for multi-resistant Escherichia coli is to use step-down therapy, and then select targeted drugs according to the results of drug sensitivity. Step-down therapy means that after patients are found to be infected with multi-drug-resistant Escherichia coli, firstly, according to the site of infection and the severity of infection, patients will be empirically treated with clinically used antimicrobial drugs to control the progression of the disease. At the same time, the drug sensitivity test for multi-drug-resistant Escherichia coli will be conducted, and then the most suitable drug for the patient and the appropriate dosage will be selected according to the results of the drug sensitivity. Patients with multiple drug-resistant Escherichia coli should be treated by their doctors to avoid delays and adverse consequences.