High transaminases may be caused by physiological reasons such as staying up all night, which may result in nausea, vomiting, loss of appetite and other clinical manifestations; they may also be caused by pathologic reasons such as viral hepatitis, which may result in jaundice, ascites, liver palms and other clinical manifestations. 1. Physiological causes: prolonged late night, fatigue, smoking, drinking, etc. can cause mild damage to liver cells, nausea, vomiting, abdominal distension, diarrhea, belching (hiccups) and other dyspeptic symptoms. 2. Pathologic causes: (1) Viral hepatitis: it is a digestive system disease caused by hepatitis virus invading liver cells, which can present systemic symptoms such as tiredness, fatigue, itchy skin; liver symptoms such as pain in the liver area, enlargement of the liver, and percussion pain in the liver area; and symptoms such as jaundice, fever, and so on, may also occur. (2) Cirrhosis: It develops from chronic liver diseases such as chronic alcoholic liver disease, and may present with symptoms such as enlarged spleen, vomiting blood, black stools, jaundice, ascites, liver palms, spider nevus, septicemia, and hepatorenal syndrome. Clinical manifestations of high aminotransferase include abdominal varicose veins, weight loss, etc. It is recommended to consult a doctor for a clear diagnosis and targeted treatment under the guidance of the doctor.