There are more than eight hypertension combination regimens, and each regimen is tailored to different populations and should be selected on a case-by-case basis. Hypertension combinations are indicated for high-risk/very high-risk individuals with blood pressure ≥160/100 mmHg or 20/10 mmHg above target, and small-dose combinations can be considered when blood pressure exceeds 140/90 mmHg. 1. Dihydropyridine calcium channel antagonist (CCB) + angiotensin receptor inhibitor (ARB), such as amlodipine + valsartan; 2. Dihydropyridine CCB + angiotensin-converting enzyme inhibitor (ACEI), e.g., amlodipine + Benadryl; 3. dihydropyridine CCB + thiazide diuretics, such as amlodipine + hydrochlorothiazide; 4. dihydropyridine CCB + beta-blocker, e.g., nitrendipine + atenolol; 5. ARB + thiazide diuretics, e.g., telmisartan + hydrochlorothiazide, etc; 6. ACEI + thiazide diuretics, such as captopril + hydrochlorothiazide. In addition, there are also second- and third-line programs such as diuretics + beta-blockers. Note: Similar drugs should not be used at the same time. The combination of blood pressure medication should be based on the individual’s specific situation to choose the appropriate program, should be under the guidance of the cardiovascular physician medication.