Penile lymphoma is generally more serious, once diagnosed patients need to actively take relevant treatment measures, so as to improve the disease and prolong the survival time. Lymphoma is a malignant lymphoma, a malignant tumor originating in the lymph nodes and lymphatic tissues. Its etiology is not yet clear, and may be caused by viral infections, other pathogenic infections, low immunity, genetics and other factors. Penile lymphoma is a more serious condition that may affect survival time, as well as quality of life. Once diagnosed with penile lymphoma, patients can take radiation therapy, chemotherapy and other comprehensive treatment, which can improve the symptoms of the disease, and early-stage patients can mostly achieve clinical cure after standardized treatment. During the treatment period, patients with penile lymphoma should also follow the doctor’s instructions for regular review and long-term follow-up, so as to understand the recovery of the disease. In daily life, keep the perineum clean and do not scratch the affected area.