Wrist and ankle acupuncture is a method of using milli-needles to prick specific areas on the wrist or ankle joints and pierce subcutaneously to treat diseases, which is one of the modern acupuncture therapies. The mechanism of action is to stimulate the superficial nerve endings through acupuncture to promote the release of neuromediators, improve microcirculation and excite the nerves to achieve the purpose of treating diseases. It has the characteristics of less acupuncture points, quicker effect, less pain, and wide application. It can treat all kinds of pain, as well as various diseases caused by the internal organs and organ disorders to which the acupuncture points belong.