The efficacy of tranexamic acid in treating melasma is more accurate, but the causes of melasma are more and more complicated, and there are actually differences in the efficacy of each patient for melasma, and the therapeutic effect and response of each patient’s melasma for tranexamic acid are also different. Tranexamic acid is a kind of hemostatic drug, which is also used more often in the clinic. It is usually recommended to take 2 times/day, 1 tablet/time of low dose treatment for 2-3 months and then observe the effect. In addition, it should be noted that this drug is a hemostatic drug, which can sometimes lead to thrombosis or affect women’s menstruation, which are some of the side effects. Meanwhile, tranexamic acid treatment will be more effective if it can be combined with other vitamin drugs, such as vitamin E and vitamin C. However, once the medication is stopped, chloasma may come back, and tranexamic acid treatment for chloasma cannot be used for a long time. The treatment of melasma is also difficult so far, and it is actually more difficult in clinical treatment if melasma is completely removed and will not recur.