The stomach is comfortable when taking H. pylori 4 in combination, but after taking the course of treatment, the stomach is not comfortable may be that the course of 4 in combination medication did not completely eliminate the presence of the disease, the emergence of drug resistance or the side effects of taking 4 in combination medication. 1. It may be that the course of treatment is insufficient, which often occurs in patients with poor adherence. In this case, it is recommended that you can choose to start a new course of 4-combination therapy again and continue treatment with the previous 4-combination medication. 2. Drug resistance may be present. Resistance is a common phenomenon during the treatment of germ infections, due to the long-term fixed treatment with the same antibiotic, for example, amoxicillin. Therefore, in this case, you can choose to change the previous 4-combination medication and use a new generation of drugs. Generally H. pylori is not resistant to the new generation of drugs, so the new generation of drugs can be chosen for the normal course of treatment. 3.4 side effects of the combination of drugs caused by discomfort, the use of any drug in the process there will be the possibility of adverse reactions, therefore, the need for professional guidance under the guidance of the doctor for the same effect of the replacement of drugs. All of the above treatments require medical consultation, reasonable and standardized examination and diagnosis and treatment.