Survival of patients with gastric cancer combined with liver metastasis is related to the disease (stage, etc.), patient’s own condition, treatment, etc., and varies from person to person; some studies say that their 5-year survival is only 16.3%. Clinical symptoms of gastric cancer combined with liver metastasis include jaundice, ascites, progressive weight loss, anemia and hypoproteinemia. Its treatment plan needs to be judged according to the condition: 1. If the metastatic lesion is located in a certain lobe of the liver or an isolated lesion with small diameter, and the general condition is good enough to tolerate surgery, surgical resection of the lesion can be chosen, with postoperative adjuvant drug treatment. 2. If the metastatic foci are large in size or number, which makes surgery more difficult, radiofrequency ablation or hepatic artery chemoembolization can be chosen. If it is difficult to tolerate radiofrequency ablation or hepatic artery embolization, chemotherapy or traditional Chinese medicine can be chosen according to the needs of the disease to control tumor growth and prolong the survival period. 3. If patients have serious systemic symptoms, poor general condition, multiple organ and tissue metastases throughout the body, and difficult to tolerate surgery, chemotherapy and radiotherapy, they can choose targeted therapy, nutritional support, albumin supplementation and other treatments in order to alleviate the clinical symptoms and improve the quality of life. However, gastric cancer metastasis to the liver is already in advanced stage, and its prognosis is related to the primary lesion, the condition of liver metastasis and treatment modality, which requires comprehensive evaluation and selection of appropriate treatment plan. The specific prognosis is still inconclusive, and some studies claim that the 5-year survival rate is only 16.3%. In conclusion, the prognosis of patients with liver metastasis of gastric cancer is poor. It is recommended that patients should go to regular hospitals to evaluate their conditions and follow the doctor’s instructions to control the progression of the disease and improve their prognosis.