Injection causing atrophy and depression in the buttocks can be given medication, physical therapy, and surgical treatment. Injection leads to atrophy of the buttock muscle and localized depression, which belongs to the wasteful muscle atrophy, and is related to the improper care during or after the injection of the muscle. The site of injection is in the outer upper 1/4 of the buttocks, that is, at the gluteus maximus muscle, and the medicine will spread along the course of muscle fibers after injection. If the injection is repeated in the same area, it will lead to frequent stimulation of the muscle bundle gap, followed by damage, resulting in muscle atrophy. Secondly, injection hip muscle atrophy may also be caused by damage to the nerve. It can be regulated through conservative treatment first, using some nutritive nerve drugs, such as methylcobalamin, nerve growth factor, with local acupuncture, massage, physiotherapy, etc., and also need to carry out functional exercise. If there is obvious depression after gluteal muscle atrophy, it means that the time is relatively long, in this case, the effect of conservative treatment is not good, then surgery is needed. It can be filled by prosthesis or fat filling. When injections cause atrophy and depression of the buttocks, the doctor should evaluate and guide the appropriate treatment plan. Take care to rotate the area with daily injections.