Low levels of ApoE are due to impaired liver function, and the appropriate amount of estrogen in a woman’s body can also affect ApoE levels. The lack of nutrient content in long-term dieting intake can also cause a decrease in body fat content. Diseases of the liver, such as hepatitis, cirrhosis, and fatty liver, can affect ApoE levels, which are usually seen in fatty liver. Apolipoprotein levels can be measured to assess liver function. The release of estrogen levels in women can also indirectly affect liver function, causing cirrhosis leading to low ApoE levels. Low apolipoprotein levels can easily lead to cardiovascular diseases, increase the incidence of coronary heart disease, and are detrimental to the maintenance of vascular elasticity, and often require clinical treatment with lipid-lowering drugs.