It is not recommended to drink coffee after drinking anti-inflammatory drugs, which may have an effect on the efficacy of anti-inflammatory drugs. In general, it is not recommended to drink coffee again after drinking anti-inflammatory drugs because caffeine, the main ingredient in coffee, may affect the effectiveness of anti-inflammatory drugs. Caffeine may potentiate the effect of the medication and increase the chance of side effects, or it may interact with the medication and counteract its effect, such as reducing the anti-inflammatory effect of the anti-inflammatory medication. Drinking coffee after drinking anti-inflammatory drugs will lead to uncertainty in the efficacy of the treatment, at the same time, coffee will cause some stimulation of the gastrointestinal tract, aggravating the burden on the stomach and intestines, and the patient is prone to stomach bloating and other uncomfortable situations. In addition, drinking tea and alcohol after taking anti-inflammatory drugs is not recommended.