The patient was a 83-year-old male with a history of gastritis and no other definite medical history. He was admitted to the hospital in December 2010 because of abdominal distension and progressive bowel difficulty for 2 months. Painless gastroenteroscopy revealed a 5*5 cm ulcerated mass in the gastric body, a cauliflower-like mass 7-13 cm from the anal verge, and an obvious narrowing of the intestinal lumen, through which the enteroscope could barely pass. The biopsy pathology confirmed that it was adenocarcinoma of the stomach and rectum, and PET-CT indicated that it was the same as that found by gastroscopy, and enhanced CT indicated that there were enlarged lymph nodes in the mesentery and retroperitoneum, thickened pelvic floor and a little fluid accumulation. The patient came to our hospital again after consultation with several hospitals. Our treatment strategy: first, transanal iodine 125 particle implantation (intertissue nuclear implantation) to control rectal adenocarcinoma and relieve defecation difficulties, which gradually takes effect after 7-10 days. After 4 months, due to the increase of epigastric fullness and a small amount of vomiting blood, the patient was treated with additional oral chemotherapeutic drugs strictly after weighing many factors, and was able to maintain self-care for 10 months (KPS score >70 for 14 months).