The dangers of rectally administered antipyretics are basically the same as those of orally administered antipyretics. Both are also basically the application of non-steroidal anti-inflammatory drugs, rectal administration of specific drugs are acetaminophen or indomethacin, oral application is also mainly these two, in addition to ibuprofen. The main hazard is the possibility of causing or aggravating peptic ulcers, and if there is a previous peptic ulcer, there is a risk of aggravating stomach pain. Rectal administration may also cause allergy, such as rash, and in severe cases, anaphylactic shock, but this is quite rare and basically not a cause for concern. The only difference between rectal administration and oral administration is the way it is administered. Rectal administration may make some people feel uncomfortable, which should be considered one of the biggest hazards of rectal administration.