Periodontitis with enlarged lymph nodes should be actively treated, if the lymph nodes are enlarged and painful, anti-inflammatory treatment is needed. Periodontitis with swollen lymph nodes may have acute inflammation in the oral cavity, and should be actively treated, including basic treatment, periodontal surgery, maintenance treatment, etc., of which the basic treatment is the most important, i.e., teaching the patient the correct way of brushing teeth, the doctor to do scaling, scraping and root planing. If lymph node enlargement is obvious and accompanied by painful symptoms, it is necessary to take anti-inflammatory drugs such as amoxicillin capsules, metronidazole and so on in conjunction with the first. The medication needs to be under the guidance of the doctor. In daily life, we should enhance the awareness of oral hygiene, brush teeth carefully twice in the morning and evening, rinse the mouth after meals, and have regular oral examination.