Low albumin and globulin on liver function tests may be caused by liver disease, but it does not necessarily reflect hepatic synthetic dysfunction, and may be caused by many other conditions, including systemic inflammation, nephrotic syndrome, and malnutrition. The normal ratio of albumin to globulin is (1.5-2.5):1, and a decrease in this ratio is most often caused by a marked decrease in albumin or a marked increase in globulin. Among them, the decrease of albumin can be seen in patients with persistent hepatitis, cirrhosis, hepatocellular carcinoma and other severe liver function damage. In addition, significantly elevated globulin concentration can be seen in M-proteinemia, such as multiple myeloma, primary macroglobulinemia; as well as other autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, etc., which can be caused by abnormally high globulin concentration resulting in a low albumin-to-globulin ratio. In summary, it is recommended to consult a doctor for standardized diagnosis and treatment when necessary.