Running may lead to elevated blood creatinine level, which may be physiological phenomenon or due to pathological factors. Blood creatinine is one of the commonly used indicators of renal function in clinic, and it is a product of muscle decomposition and metabolism in human body. When people run for exercise, with the metabolic decomposition of muscle, the creatinine produced will increase, so there will be a physiological increase in blood creatinine level, such as in the normal population is usually a mild increase, usually after the removal of triggers can be quickly restored to the normal range. Running may also cause pathological increase in blood creatinine level. When rhabdomyolysis is triggered by excessive high-intensity running exercise, it will cause large amount of creatine kinase and myoglobin production, which may trigger acute renal impairment, thus leading to a sharp increase in blood creatinine level, and the patient may suffer from fever, fatigue, oliguria, anuria, etc. in addition to muscle pain. If the blood creatinine level rises after running, it is recommended to consult a doctor in time and complete the relevant examinations according to the doctor’s instructions, in order to clarify the cause of the disease and treat the symptoms.