Precision radiotherapy is one of the effective means to treat pancreatic cancer. Precision radiotherapy usually refers to three-dimensional stereotactic intensity-modulated radiotherapy, particle implantation radiotherapy, etc., and patients with pancreatic cancer can receive precision radiotherapy. The indications of radiotherapy are broad and selective. Adverse effects of radiotherapy can cause generalized weakness, nausea and vomiting, etc. Local discomfort can also be caused by radiotherapy. Three-dimensional conformal intensity-modulated radiotherapy has the advantages of a wide range of radiation therapy, no anesthesia, no incision, less pain, less negative effects, no infection, accurate positioning, etc.; in the process of treatment, it adopts the targeting therapy to treat the tumor site of the patient accurately, and reduces the dose of non-tumor sites. According to some studies, with 3D conformal intensity-modulated radiotherapy combined with chemotherapy for the treatment of pancreatic cancer, the 1- and 2-year survival rates of patients were 60% and 28%, respectively, and the median survival period was 15 months. Pancreatic cancer patients can undergo precision radiotherapy, and if discomfort occurs, they should actively contact the attending physician to avoid adverse consequences.