A positive second and fifth of the Hepatitis B Penta means that the Hepatitis B Penta is positive for Hepatitis B Surface Antibodies and Hepatitis B Core Antibodies. Surface antibodies to Hepatitis B are protective antibodies that can come from getting the Hepatitis B vaccine or from having been infected with the Hepatitis B virus once. Surface antibodies are acquired from infection with the hepatitis B virus when the virus is cleared by the body’s immune system, which is manifested by positive hepatitis B surface antibodies, positive hepatitis B core antibodies, and sometimes positive hepatitis B e antibodies. Hepatitis B core antibodies are caused by the body’s immune system coming into contact with the hepatitis B core antigen, which does not appear in the hepatitis B vaccine, but only in the hepatitis B virus. Therefore, the second and fifth positive cases are those who have been infected with the hepatitis B virus before, and the body is now in a state of healing.