Mild thalassemia does not turn into moderate thalassemia. Thalassemia is a hereditary disease caused by an inherited DNA mutation that causes a disorder in the synthesis of the patient’s peptide chain, resulting in a series of symptoms such as hemolytic anemia. Thalassemia is a hereditary disease and the genetic defect cannot be changed, so it is impossible to change from thalassemia minor to thalassemia moderate. Patients with mild thalassemia usually do not have obvious clinical symptoms or anemia, but only during routine blood tests, it can be found that the patient’s average red blood cell volume is small and the amount of red blood cells and average hemoglobin is also reduced, but the hemoglobin is normal. Although mild thalassemia will not turn into moderate thalassemia, if the patient has an infection, such as a cold, it may induce an aggravation of thalassemia, such as an aggravation of hemolysis, but this situation is only temporary and it is not possible to change from mild thalassemia to moderate thalassemia.