Some types of toothache can be treated with metronidazole with amoxicillin to relieve the pain, while some are ineffective. 1. Toothache is mainly categorized into endodontic-related diseases, periodontal tissue-related diseases, wisdom tooth pericoronitis, and manifestations of systemic diseases in the oral cavity. The oral cavity is a complex environment where many kinds of bacteria coexist, and aerobic and anaerobic bacteria coexist. 2. For the oral cavity itself is mostly caused by bacterial infections, so taking the treatment of anaerobic bacteria metronidazole and treatment of sensitive bacteria amoxicillin usually have a certain effect, but most of them are alleviating the effect. For some acute pulpitis, deep caries caused by hot and cold or sweet and sour pain and systemic diseases in the oral cavity manifestations, taking metronidazole and amoxicillin usually have no effect. In addition, the drug is mostly a relief effect, can not be cured, it is recommended to go to the regular hospital stomatology department consultation and treatment, the use of drugs need to follow the doctor’s instructions.