Hepatobiliary duct stones with cholangitis, it is best to take timely surgical treatment, because conservative treatment of this condition will not have too good an effect, only through surgery to achieve clinical cure. 1. If the patient has choledocholithiasis with cholangitis, it is necessary to actively inject anti-inflammatory drugs intravenously, such as ceftazidime for injection, levofloxacin lactate sodium chloride injection, metronidazole injection and other drugs for anti-infection treatment. Antibiotics can be used to control the infection, and after the infection is initially controlled, then cholangiopancreatography (ERCP) can be used to remove the stone. 2. If intrahepatic choledocholithiasis is difficult to remove the stone, partial hepatectomy or segmental hepatectomy can be considered after anti-infection treatment. 3. If the hepatic bile duct stones are large and accompanied by cholangitis symptoms, laparoscopy combined with choledochoscopy can be considered. Generally, cholangitis symptoms will improve after stone removal. Patients with hepatic bile duct stones with cholangitis should follow the doctor’s instructions to actively cooperate with the doctor’s treatment, do not self-medication, in order to avoid delaying the condition or adverse reactions.