Hepatitis B is hopefully curable, but the specific situation needs to be judged according to the actual condition of the patient. Hepatitis B is caused by hepatitis B virus infection, which is more common in the clinic and can be categorized into acute hepatitis B and chronic hepatitis B according to the speed of development of the patient’s condition. First of all, acute hepatitis B has a good prognosis, and most patients can be cured in 3-6 months through active treatment, bed rest and improvement of living habits. Secondly, although chronic hepatitis B is a refractory disease, for patients with milder condition, by seeking medical treatment as early as possible and using nucleotide analogs such as entecavir and lamivudine as well as interferon drugs such as polyethylene glycol interferon-alpha and common interferon-alpha under the guidance of doctors for antiviral treatment, viral replication can be effectively suppressed, thus achieving the goal of cure. Meanwhile, for patients with more serious condition, if cirrhosis or liver failure occurs, liver transplantation can also achieve the goal of cure, but they need to follow the doctor’s instructions to take long-term antiviral drugs, such as entecavir, in order to avoid recurrence of the disease. To summarize, the prognosis of acute hepatitis B is good, the prognosis of mild chronic hepatitis B is also good, although the prognosis of severe chronic hepatitis B is worse, but there is a possibility of cure, we suggest that patients seek medical treatment as soon as possible to avoid delaying the condition. Drugs should be used under the guidance of a professional physician, and should not be used arbitrarily.