If the thumb blisters, in the elimination of the following diseases need to pay attention to the treatment: 1, shingles, usually can occur in the thumb, palm and the ipsilateral upper limb appear clustered distribution of several or more than ten blisters, accompanied by tingling or burning sensation; in clinical treatment need to take oral valacyclovir hydrochloride or sedative acyclovir injection for antiviral treatment, while the need for topical acyclovir ointment or more The treatment is mainly due to local bacterial infection caused by fish, shrimp, crab and other prick wounds, which can appear in the thumb redness and swelling, and blisters on its surface.