The difference between physiologic and pathologic vitreous clouding includes the cause, symptoms and treatment options will be different. 1. Etiology: Physiologic vitreous clouding is mostly caused by age-related changes in the vitreous body and is common in the elderly. Pathologic vitreous clouding has no obvious age limitation, and may be caused by ocular trauma, vitreous hemorrhage, intraocular inflammation, high myopia, retinal diseases, and so on. 2. Symptoms: Physiologic vitreous clouding will show small floating dots or filaments in front of the eyes. Pathological vitreous clouding will show a sudden or gradual appearance of dark shadows and red mist, which may be accompanied by visual field defects or visual obstruction, and may affect vision if not treated in time. 3. Treatment: physiologic vitreous clouding, if it does not affect vision, generally do not need special treatment, regular follow-up can be. Pathological vitreous clouding needs to be treated with the right medication, laser or surgery for the cause of the disease. It is recommended that patients with vitreous clouding go to the hospital for relevant examinations, and then under the guidance of the doctor for targeted treatment.