High red blood cell volume may be caused by physiological reasons, or by pathological reasons such as megaloblastic anemia, hemolytic anemia, true erythrocytosis, etc. The treatment methods for different reasons are different, and the commonly used treatment method is drug treatment. 1. Physiological reasons: oral contraceptive pills, pregnancy, long-term alcohol consumption can lead to high red blood cell volume, generally do not need special treatment, after a period of time can return to normal. 2. Megaloblastic anemia: patients can be treated by oral folic acid, if there is an obstacle to intestinal absorption of patients, intramuscular injection of calcium tetrahydrofolate, patients can also take oral vitamin B12 tablets or intramuscular injection of vitamin B12. 3. Hemolytic anemia: patients can follow the doctor’s instructions to use glucocorticoids for treatment, commonly used drugs are prednisone tablets, dexamethasone tablets, etc., if glucocorticoid treatment is ineffective, but also comply with the doctor’s instructions for the use of immunosuppressive drugs, such as compound cyclophosphamide tablets, azathioprine tablets, if the effect of conservative treatment is not obvious, but also comply with the doctor’s instructions for surgical treatment, such as splenectomy, allogeneic hematopoietic stem cell transplantation. 4. True erythrocytosis: hydroxyurea and other drugs can be given orally to inhibit the abnormal proliferation of bone marrow red lineage. Specific treatment methods or go to the hospital to confirm the diagnosis, under the guidance of the doctor to choose, the patient must not unauthorized use of drugs, stop or change drugs.