Hypopituitarism (Simon-Sihan syndrome) is a clinical syndrome that presents with inadequate secretion of adenohypophyseal hormones due to multiple etiologies, secondary to hypogonadal, thyroid, and adrenocortical function. In Silhan syndrome, the gonads are hypogonadal and the ovaries are significantly reduced in women. The uterus and mammary glands are atrophied. There is a dramatic decrease in the secretion of various hormones due to adenopituitary lesions, with insufficient secretion of thyroid hormones, adrenocortical hormones, and sex hormones. How can hypopituitarism be effectively prevented and treated? If the area of pituitary necrosis is <50%, because the damage is relatively mild, the anterior lobe tissue can be repaired through regeneration, so the clinical symptoms are not obvious, and there can be no symptoms or only partial dysfunction. If the pituitary necrosis area accounted for 60%, there can be mild symptoms destruction accounted for 75%, there can be moderate symptoms destruction area of 95%, there are severe symptoms. When necrosis and atrophy of the pituitary tissue occur, the endocrine glands associated with it, such as the thyroid, gonads, and adrenal cortex, are altered and atrophied to varying degrees. Generally, the response to gonadotropin and lactogenic changes appears earlier, and clinical symptoms such as no lactation after delivery, amenorrhea, loss or disappearance of libido, and atrophy of genitalia and breast appear. Prednisone given orally or dexamethasone given intravenously may reduce symptoms and jaundice and may even bring about remission of acute liver failure. Prednisone alone or in combination with other immunosuppressive agents was the conventional treatment for chronic hepatitis abroad until the 1970s, and a number of randomized controlled clinical trials have confirmed that it can prolong survival and reduce morbidity and mortality. However, after the establishment of HBsAg testing methods, it was found that the treatment groups previously reported to be effective contained mostly HBSA8(-) cases, most likely with autoimmune hepatitis.