Cutaneous mucin deposition symptoms are caused by a marked increase in hyaluronic acid, acidic mucopolysaccharide, and mucin, which is deposited diffusely or restrictively in the skin. The lesions are light red single or multiple papules or nodules, approximately 2 cm in diameter, with smooth epidermis, and can be seen anywhere on the body surface. There are no conscious symptoms and it can heal spontaneously. Prednisolone 20 mg/d was applied for 6 weeks, and there was significant clinical and peripheral blood smear improvement. Maintenance with prednisolone 7.5-10mg/d after the rash subsides can control the disease.