The vague pain in the stomach after eating a full meal is usually considered to be related to indigestion, and the discomfort can be relieved by taking certain medications, such as domperidone, mosapride, digestive enzyme preparations and so on. The stomach ache after eating a full meal is considered to be related to indigestion, taking gastrointestinal stimulants can promote the food in the stomach to enter the duodenum, reduce the burden on the stomach, and alleviate the symptoms of postprandial bloating and pain, common drugs include domperidone and mosapride. In addition, digestive enzyme preparations can be used as adjunctive medication for patients with dyspepsia to help digestion and absorption of food, and to improve abdominal pain, epigastric bloating, and poor appetite associated with meals. In the case of vague pain in the stomach after eating a full meal, it is recommended to actively seek medical treatment under the guidance of a professional physician to avoid delays in the condition.