Treatment of non-gonorrhea is still dominated by antibiotic therapy. Non-gonococcal urethritis refers to pathogens other than Neisseria gonorrhoeae, of which Chlamydia trachomatis and mycoplasma infections are common, and most are still sexually transmitted. The symptoms of non-gonococcal urethritis are similar to gonorrhea urethritis in that they are often accompanied by painful urination and urethral discharge that is yellowish or purulent in color, and sometimes increased leucorrhea in women. 20%-50% of the population does not have obvious clinical symptoms and is often detected by physical examination. Treatment is still based on the use of appropriate and sensitive antibiotics for the pathogenic bacteria. For example, macrolide antibiotics such as azithromycin or roxithromycin are preferred for mycoplasma and Chlamydia trachomatis. As drug-resistant bacteria continue to emerge, the choice of antibiotics is changing and escalating. In addition to the application of antibiotics, general treatment such as drinking plenty of water and keeping clean is also important. In summary, the treatment of non-gonococcal urethritis is still based on antibiotic treatment, and the pathogenic bacteria infection needs to be clarified before treatment, and timely symptomatic treatment, of course, treatment and prevention should go hand in hand, the patient’s towels, underwear or bath tubs should also be separated, and sexual partners also need to be treated at the same time.