Hepatitis B 5, i.e. Hepatitis B two halves, is positive for items 1, 2 and 5 in the early stage of subclinical hepatitis B virus infection or secondary infection with different subtypes of hepatitis B virus. Hepatitis B two-half positive items 1, 2 and 5 are positive for hepatitis B surface antigen, hepatitis B surface antibody and hepatitis B core antibody. Positive surface antigen indicates current hepatitis B infection; hepatitis B antibody is a protective antibody, and its positivity indicates immunity; positive hepatitis B core antibody indicates previous infection with hepatitis B virus. Positive hepatitis B core antibody indicates a previous hepatitis B virus infection. Positive hepatitis B core antibody can be seen in the early stage of subclinical hepatitis B virus infection or secondary infection with different subtypes of hepatitis B virus, which indicates that there is replication of hepatitis B virus. It is recommended to consult the doctor in time, complete the examination of hepatitis B virus DNA and liver function, and carry out treatment under the guidance of professional doctors.