”Herpes zoster, the medical name for the disease, is a common condition that manifests itself clinically as a cluster of herpes along a nerve on one side of the body and unbearable pain. Many patients experience a gradual reduction in pain after the herpes disappears, but some patients still have pain that lasts for months, years or even a lifetime, called postherpetic neuralgia. Severe pain makes it difficult for patients to sleep and eat, and chronic pain leads to psychiatric symptoms such as depression, anxiety, and in severe cases, suicidal tendencies. Some studies have shown that the older the patient is, the more likely it is that postherpetic neuralgia occurs in the elderly. Older adults tend to have a variety of other comorbidities, such as hypertension, diabetes, and coronary artery disease. Severe pain can exacerbate these diseases to varying degrees, leading to increasing misery in the later years of life for the elderly. In order not to suffer from postherpetic neuralgia, we need to actively face the “Pancreatic Dragon” and not take it lightly. How to face it positively? If you have shingles, first of all, don’t be afraid to know that the disease is caused by the varicella-zoster virus infection and is not life-threatening, except for severe pain. The initial infection of this virus is manifested as chickenpox, and after the chickenpox is healed, this virus is latent in the body at the ganglion. When the patient’s immunity decreases (infection, exertion, mental shock, application of radiotherapy and chemotherapy, immunodeficiency disease, etc.), this virus is activated again and invades one or several nerves, producing pain and a rash along these affected nerves. Secondly, one should go to a hospital for standardized treatment, and it can be said that the more timely the treatment is, the less likely it is that postherpetic neuralgia will occur. What is aggressive treatment? Dermatology tends to focus only on the herpes on the skin so that it subsides as quickly as possible. While it is important to prevent local infection, early treatment of pain is even more important to prevent postherpetic neuralgia. Treatment consists mainly of pharmacological and non-pharmacological treatments. The main measures of pharmacological treatment are early application of antiviral drugs and regular and quantitative application of mild analgesics such as acetaminophen and NSAIDs. Tricyclic antidepressants not only reduce pain to promote sleep, but early application can reduce the likelihood of postherpetic neuralgia. Non-pharmacological treatments are mainly local nerve blocks and physical therapy. Does it mean that there is nothing that can be done to develop postherpetic neuralgia? Objectively speaking, there are indeed some difficulties in the treatment of postherpetic neuralgia, but it is not drug-free. There are many patients who have been suffering from pain for several years, almost without hope for treatment, and who have improved and regained their cheerfulness through the comprehensive treatment in our center. International guidelines suggest that tricyclic antidepressants, antiepileptics and lidocaine patches are the first-line drugs; opioids and tramadol are the second-line drugs; and capsaicin patches and sodium valproate (Depakene) are the third-line drugs. There is a wide variety of non-pharmacologic treatments, including nerve blocks, physical therapy, electrophysiological and neuromodulation procedures, pulsed radiofrequency and ozone therapy, psychotherapy, and immunotherapy. For elderly patients with more comorbidities, drug combination with non-drug treatment is recommended to minimize the side effects of drugs. Therefore, don’t worry about having “Pancreatic Dragon” and treat it early; don’t worry about having postherpetic neuralgia either, face it bravely and treat it actively with conviction. We believe that through the joint efforts of you and me, the torturous postherpetic neuralgia will no longer affect our happy life in our old age!